PyRosetta

Welcome to PyRosetta!

PyRosetta is an interactive Python-based interface to the powerful Rosetta molecular modeling suite. It enables users to design their own custom molecular modeling algorithms using Rosetta sampling methods and energy functions.

PyRosetta v1.0 is now available! Please see the downloads page for more information.

Latest News

Get the latest updates through our new PyRosetta Twitter feed!

10/15/09 - PyRosetta was used by Dr. Donald Berkholtz and colleagues at Oregon State University to study ideal and non-ideal peptide bond geometries. Their work is published in the current issue of Structure.

9/29/09 - PyRosetta v1.0 is now available for download. We also have an updated tutorial and an expanded user's manual. The user forums are also up and running.

9/22/09 - DNA/RNA modeling, in the example case of a protein-DNA docking script is now available.

9/02/09 - A script demonstrating structure-based mutation analysis with Alanine scanning is now available. It uses side-chain packing to mutate interface residues in a protein complex and calculates its effect on binding.

8/20/09 - Small-molecule modeling/docking capabilities have now been added to PyRosetta. A sample script can be found here.

9/1/08 [archived] - PyRosetta is featured in this month's issue of Johns Hopkins Engineering Magazine.