Our lab vision is to employ and extend protein structure prediction methods to solve practical problems in biomolecular self-assembly and function.

In particular, we specialize in protein-protein docking, therapeutic antibodies, protein-solid surface interactions, and allostery. Rapid conformational search methods and accurate free energy functions have enabled unprecedented new abilities in structure prediction. We are pushing these techniques toward realistic biological and engineering problems and in the process developing additional methods capable of handling, for example, large proteins, proteins for which homology models must be used for docking, proteins which change conformation to affect function (allostery), and proteins which undergo conformational change upon binding.