The goal of our research is to create and apply protein structure prediction methods to solve practical problems
in self-assembly and function in biomolecular engineering.
In particular, we specialize in protein-protein docking,
therapeutic antibodies, protein-solid surface interactions, and allostery. Rapid conformational search
methods and accurate free energy functions have enabled unprecedented new abilities in structure prediction.
We are pushing these techniques toward realistic biological and engineering problems and in the process
developing additional methods capable of handling, for example, large proteins, proteins for which homology
models must be used for docking, proteins which change conformation to affect function (allostery),
and proteins which undergo conformational change upon binding.